View at Publisher | View at Google Scholar Enebo LB, Berthelsen KK, Kankam M, Lund MT, Rubino DM, et al
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Studies also indicate that it plays a vital role in cellular metabolism, DNA repair, and brain function
This instability of heterochromatin structure is closely associated with cancer development and could be partly repaired by histone methyltransferase SETDB1 that is specifically recruited to the UV-damaged heterochromatic regions and maintains the H3K9me3 modification on newly deposited H3 histones, helping to protect the cell from the effects of genomic instability [153]
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